Anti-tissue transglutaminase IgA (anti-tTG IgA) is a blood test that is used to help diagnose celiac disease, an autoimmune disorder that affects the small intestine.
Celiac disease is caused by a sensitivity to gluten, which is a protein found in wheat, barley, and rye. When someone with celiac disease eats gluten, their immune system reacts by attacking the lining of their small intestine. This can damage the small intestine and prevent the absorption of nutrients from food, leading to digestive problems, malnutrition, and other health issues.
Anti-tissue transglutaminase IgA is one of several blood tests that may be used to diagnose celiac disease. It measures the levels of antibodies against tissue transglutaminase, an enzyme that is involved in the immune response to gluten. High levels of anti-tTG IgA are a sign that a person’s immune system has been reacting to gluten and may indicate that they have celiac disease.
It’s important for people who are experiencing symptoms of celiac disease or who have a family history of the condition to talk to their healthcare provider about testing. Diagnosis and treatment can help prevent complications associated with celiac disease, including malnutrition, osteoporosis, and neurological problems. Treatment typically involves a gluten-free diet, which can be challenging but is necessary for managing the condition.
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